Precision ASO Design for RNA Therapeutics
Computational ASO design services powered by ASOwalker™ — developed by RNA scientists with direct experience in FDA-approved ASO drug programs.
The Challenge
ASO design traditionally relies on approaches that are slow, expensive, and fragmented.
Trial and error
Synthesizing dozens of candidates hoping a few work
Scattered expertise
Deep knowledge locked in pharma silos
Slow iteration
Months of optimization per program
What We Deliver
Target Analysis
Complete gene/transcript characterization, isoform mapping, exon-intron architecture
ASO Candidates
Ranked, optimized sequences with clear scientific rationale for each recommendation
Off-Target Report
Transcriptome-wide specificity analysis with expression-weighted risk stratification
Chemistry Recommendations
Backbone, sugar modifications, and architecture optimized for your mechanism and target tissue
Synthesis-Ready Files
Sequences formatted for direct vendor ordering (IDT, Dharmacon, Eurogentec, etc.)
Five ASO Mechanisms Supported
RNase H Knockdown
Gapmer designs for mRNA degradation
Exon Skipping
Block splice enhancers to skip disease-causing exons
Exon Inclusion
Block splice silencers to restore exon inclusion
Translation Blocking
Steric block of ribosome binding
Expression Enhancement
Target upstream regulatory elements to increase protein
Service Tiers
Flexible options for every stage of your ASO program.
Basic Screening
$500 – $1,000
Target feasibility assessment
Best for: Academic labs, early feasibility studies
Standard Design
$2,000 – $3,000
Comprehensive ASO strategy
Best for: Biotech R&D, serious lead identification
Advanced Consulting
$4,000+
Enterprise partnership
Best for: Pharma programs, IND-enabling work
Our Process
Consultation
Discuss your target, goals, and timeline
Target Analysis
Comprehensive gene/transcript characterization
ASO Design
Generate and rank optimized candidates
Validation Report
Off-target analysis, chemistry recommendations
Delivery
Synthesis-ready files, detailed documentation
Support
Revision rounds, ongoing consultation
What Makes Us Different
Deep RNA Expertise
Founded by a PhD molecular biologist trained in Alberto Kornblihtt's lab (UBA/CONICET) — a global leader in RNA splicing. Direct collaboration with Dr. Adrian Krainer's group, pioneers of Nusinersen.
Computational Precision
Our ASOwalker™ platform integrates multiple layers of biological evidence and validated design principles to systematically evaluate and rank ASO candidates with high confidence.
Mechanism Expertise
We don't just generate sequences — we understand why they should work. Every recommendation comes with scientific rationale grounded in published literature.
Global Service
100% virtual consultancy. We serve clients worldwide with seamless collaboration across time zones.
Patient-Driven Mission
Rooted in work with patient advocacy groups (FAME Argentina, CureSMA). We understand the urgency of rare disease drug development.
Who We Serve
Academic Research Labs
Biotech & Pharma
Rare Disease Foundations
Ready to Accelerate Your ASO Program?
Free consultation — discuss your project, no obligation. We'll help you understand what's possible and what it takes.
Web: www.asolutions-therapeutics.com
© 2026 ASOlutions™. ASOlutions and ASOwalker are trademarks. This document is for informational purposes and does not constitute medical advice.